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Lilibeth A. Salvador-Reyes, Ph.D. – Professor, Deputy Director for Instruction

Contact:
lsreyes@msi.upd.edu.ph

Education:
Ph.D. in Pharmaceutical Sciences-Medicinal Chemistry, University of Florida

Research Interests:
Medicinal and Natural Products Chemistry, Biochemistry, Pharmacology

 

Click to Visit: Marine Pharmacognosy Laboratory

Selected Publications:

  • Acyatan, Z.G., Susana-Guevarra, S.R., Picart, M.R.D., Belen, E.L., Salvador-Reyes, L.A., & Concepcion, G.P. (August 20, 2024 – accepted). In vivo anti-tumor and anti-metastatic activity of renieramycin M and doxorubicin combination treatments on 4T1 breast cancer murine model. SciEnggJ, 17(Supplement), 379-390. https://doi.org/10.54645/202417SupNLT-14
  • Casanova, J.R., Villaraza, A.J.L., & Salvador-Reyes, L.A. (18 March 2024). Synthesis and biological evaluation of cyanobacterial-inspired peptides. SciEnggJ, 17 (Supplement), 43-88. https://doi.org/10.54645/202417SupJEA-58
  • Fernando, J.C., Batucan, J., Peran, J., Salvador-Reyes, L., & Villaraza, A.J. (2024). The wheel of fortune: Helical wheel alanine scanning of a spider venom antimicrobial peptide reveals residues involved in antimicrobial and cytotoxic activity. ChemMedChem, e202400488. https://doi.org/10.1002/cmdc.202400488 (Article in Press)
  • Peran, J.E., & Salvador-Reyes, L.A. (23 May 2024). Modified oxylipins as inhibitors of biofilm formation in Staphylococcus epidermidis. Frontiers in Pharmacology, 15, 1379643. https://doi.org/10.3389/fphar.2024.1379643
  • Azcuna, M.E.M., Acyatan, Z., Manzano, G., Yu, C., Aliño, P.A.M., Altamia, M., Salvador-Reyes, L.A., & Concepcion, G. (2023). Genistein and daidzein from a sponge-associated fungus (Family: Microstromataceae) show dose and incubation time-dependent Ca2+ influx activity variation. SciEnggJ, 16(Supplement), 90-106. https://doi.org/10.54645/LIJI19166
  • Gloria, P.C.T., Romines, E.M., Punzalan, M.J.D., Florece, C.M.C., Cadorna, K.E., Salvador-Reyes, L.A., & Lluisma, A.O. (2023). Genome mining of a novel marine sponge symbiont Nocardia sp. BML15-R-026U reveals high biosynthetic potential for secondary metabolites, including a non-ribosomal peptide and a polyketide of high novelty. SciEnggJ, 16(Supplement), 107-129. https://doi.org/10.54645/XSNN78625
  • Malto, Z.B.L., Reyes, J.M., Lo, B.I.D.C., Davis, B.S., Concepcion, G.P., & Salvador-Reyes, L.A. (2023). Genomics and metabolomics-based assessment of the biosynthetic potential of the sponge-associated microorganism Streptomyces cacaoi strain R2A-843A from the Philippines. SciEnggJ, 16(Supplement), 67–89. https://doi.org/10.54645/MFFR36805
  • Manzano, G., Lalas, J.A., Desabelle, L.A., Prado, M.S., Aliño, P.M., Salvador-Reyes, L., & Baria-Rodriguez, M.V. (2023). Open sea farming protocols for the Philippine blue sponge (33 pp.). University of the Philippines Marine Science Institute.
  • Malto, Z.B.L., Benico, G.A., Batucan, J.D., Cruz, J.D., Romero, M.L.J., Azanza, R.V., & Salvador-Reyes, L.A. (04 February 2022). Global mass spectrometric analysis reveals chemical diversity of secondary metabolites and 44-methylgambierone production in Philippine Gambierdiscus strains. Frontiers in Marine Science, 8, 767024. https://doi.org/10.3389/fmars.2021.767024
  • Susana, S.R., & Salvador-Reyes, L.A. (22 March 2022). Anti-inflammatory activity of monosubstituted xestoquinone analogues from the marine sponge Neopetrosia compacta. Antioxidants, 11(4), 607. https://doi.org/10.3390/antiox11040607
  • Villacorta, J.B., Rodriguez, C.V., Peran, J.E., Batucan, J.D., Concepcion, G.P., Salvador-Reyes, L.A., & Junio, H.A. (21 November 2022). Mining small molecules from Teredinibacter turnerae strains isolated from Philippine Teredinidae. Metabolites, 12(11), 1152. https://doi.org/10.3390/metabo12111152
  • Batucan, J.D., Susana, S.R., Ochoa, M.M.T., & Salvador-Reyes, L.A. (October 2021). Biological activity and chemical profiling of terrestrial and freshwater cyanobacteria from the Philippines. Philippine Journal of Science, 150(5), 1245-1254. https://doi.org/10.56899/150.05.34
  • Elsadek, L.A., Matthews, J.H., Nishimura, S., Nakatani, T., Ito, A., Gu, T., Luo, D., Salvador-Reyes, L.A., Kakeya, H. & Luesch, H. (May 14, 2021). Genomic and targeted approaches unveil the cell membrane as a major target of the antifungal cytotoxin amantelide A. ChemBioChem, 22(10), 1790–1799. https://doi.org/10.1002/cbic.202000685
  • Subong, B.J.J., Lluisma, A.O., Azanza, R.V., & Salvador-Reyes, L.A. (2021). Differentiating two closely related Alexandrium species using comparative quantitative proteomics. Toxins, 13(1), 7. https://doi.org/10.3390/toxins13010007
  • Subong, B.J.J., Malto, Z.B.L., Lluisma, A.O., Azanza, R.V., & Salvador-Reyes, L.A. (11 December 2021). Biochemical mapping of Pyrodinium bahamense unveils molecular underpinnings behind organismal processes. International Journal of Molecular Sciences, 22(24), 13332. https://doi.org/10.3390/ijms222413332
  • Al-Awadhi, F.H., Salvador-Reyes, L.A., Elsadek, L.A., Ratnayake, R., Chen, Q.Y., & Luesch, H. (June 19, 2020). Largazole is a brain-penetrant class I HDAC inhibitor with extended applicability to glioblastoma and CNS diseases. ACS Chemical Neuroscience, 11(13), 1937-1943. https://doi.org/10.1021/acschemneuro.0c00093
  • Chua, V.M., Gajewiak, J., Watkins, M., Espino, S.S., Ramiro, I.B.L., Omaga, C.A., Imperial, J.S., Carpio, L.P.D., Fedosov, A., Safavi-Hemami, H., Salvador-Reyes, L.A., Olivera, B.M., & Concepcion, G.P. (7 August 2020). Purification and characterization of the pink-floyd drillipeptide, a bioactive venom peptide from Clavus davidgilmouri (Gastropoda: Conoidea: Drilliidae). Toxins, 12(8), 508. https://doi.org/10.3390/toxins12080508
  • Lacerna II, N.M., Ramones, C.M.V., Robes, J.M.D., Picart, M.R.D., Tun, J.O., Miller, B.W, Haygood, M.G., Schmidt, E.W., Salvador-Reyes, L.A., & Concepcion, G.P. (20 December 2020). Inhibition of biofilm formation by modified oxylipins from the shipworm symbiont Teredinibacter turnerae. Marine Drugs, 18(12), 656. https://doi.org/10.3390/md18120656
  • Olano, D.E.B., Salvador-Reyes, L.A., Montaño, M.N.E., & Azanza, R.V. (January 2020). Sorption of paralytic shellfish toxins (PSTs) in algal polysaccharide gels. Algal Research, 45, 101655. https://doi.org/10.1016/j.algal.2019.101655
  • Andres, J.K., Yñiguez, A.T., Maister, J.M., Turner, A.D., Olano, D.E.B., Mendoza, J., Salvador-Reyes, L., Azanza, R.V. (9 August 2019). Paralytic shellfish toxin uptake, assimilation, depuration, and transformation in the southeast asian green-lipped mussel (Perna viridis). Toxins, 11(8), 468. https://doi.org/10.3390/toxins11080468
  • Azcuna, M., Salvador-Reyes, L., Tun, J., Lluisma, A., Uy, I.D., Cunanan, L., Siringan, M.A., & Concepcion, G.P. (2019). Characterization of the biosynthetic potential of the β-proteobacterium Achromobacter xylosoxidans strain ISP2-142-O-2-A using microbiological, chemical, and genomic approaches. Philippine Journal of Science, 148(S1), 199-209. https://philjournalsci.dost.gov.ph/images/pdf/special_issue/148_S1/characterization_of_the_biosynthetic_potential_.pdf
  • Lacerna, N.M., Miller, B.W., Lim, A.L., Tun, J.O., Robes, J.M.D., Cleofas, M.J.B., Lin, Z., Salvador-Reyes, L.A., Haygood, M.G., Schmidt, E.W., & Concepcion, G.P. (February 22, 2019). Mindapyrroles A-C, pyoluteorin analogues from a shipworm-associated bacterium. Journal of Natural Products, 82(4), 1024-1028. https://doi.org/10.1021/acs.jnatprod.8b00979
  • Liang, X., Luo, D., Yan, J.L., Rezaei, M.A., Salvador-Reyes, L.A., Gunasekera, S.P., Li, C., Ye, T., Paul, V.J., & Luesch, H. (February 19, 2019). Discovery of amantamide, a selective CXCR7 agonist from marine cyanobacteria. Organic Letters, 21(6), 1622-1626. https://doi.org/10.1021/acs.orglett.9b00163
  • Mendoza, C.B., Masacupan, D.J.M., Batoctoy, D.C.R., Yu, E.T., Lluisma, A.O., & Salvador-Reyes, L.A. (July 2019). Conomarphins cause paralysis in mollusk: Critical and tunable structural elements for bioactivity. Journal of Peptide Science, 25(7), e3179. https://doi.org/10.1002/psc.3179
  • Santiago, V.S., Manzano, G.G., Yu, C.C., Aliño, P.M., & Salvador-Reyes, L.A. (15 March 2019). Mariculture potential of renieramycin-producing Philippine blue sponge Xestospongia sp. (Porifera: Haplosclerida). Aquaculture, 502, 356-364. https://doi.org/10.1016/j.aquaculture.2018.12.059
  • Tun, J.O., Salvador-Reyes, L.A., Velarde, M.C., Saito, N., Suwanborirux, K., & Concepcion, G.P. (16 September 2019). Synergistic cytotoxicity of renieramycin M and doxorubicin in MCF-7 breast cancer cells. Marine Drugs, 17(9), 536. https://doi.org/10.3390/md17090536
  • Cai, W.; Salvador-Reyes, L. A.; Zhang, W.; Chen, Q. Y.; Matthew, S.; Ratnayake, R.; Seo, S. J.; Dolles, S.; Gibson, D. J.; Paul, V. J.; Luesch H. Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing. ACS Chem Biol. 2018, 13, 91-99.
  • Al-Awadhi, F. H.; Salvador, L. A.; Law, B. K.; Paul, V. J.; Luesch, H. Kempopeptin C, a novel marine-derived serine protease inhibitor targeting invasive breast cancer. Mar. Drugs 2017, 15, 290.
  • Al-Awadhi, F.H.; Salvador, L.A.; Luesch, H. 2015. Screening strategies for drug discovery and target identification. Marine Biomedicine Beach Bedside. Boca Raton, Fl: CRC Press 135–166.
  • Engene, N.; Tronholm, A.; Salvador-Reyes, L. A.; Luesch, H.; Paul, V. J. Caldora penicillata gen. nov., comb. nov. (Cyanobacteria), a pantropical marine species with biomedical relevance J. Phycol. 2015, 51, 670–681.
  • Salvador-Reyes, L. A.; Sneed, J.; Paul, V.J.; Luesch, H. Amantelides A and B, Polyhydroxylated macrolides with differential broad-spectrum cytotoxicity from a Guamanian marine cyanobacterium. J. Nat. Prod. 2015, 78, 1957–1962.
  • Salvador-Reyes, L. A.; Engene, N.; Paul, J.; Luesch, H. Targeted natural products discovery from marine cyanobacteria using combined phylogenetic and mass spectrometric evaluation. J. Nat. Prod. 2015, 78, 486–492.
  • Salvador-Reyes, L. A. and Luesch, H. Biological targets and mechanisms of action of natural products from marine cyanobacteria. Nat. Prod. Rep. 2015, 32, 478–503.
  • Salvador, L. A.; Park, H.; Al-Awadhi, F. H.; Liu, Y.; Kim, B.; Zeller, S. L.; Chen, Q.; Hong, J.; Luesch, H. Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties. ACS Med. Chem. Lett. 2014, 5, 905-910.
  • Kim, B.; Park, H.; Salvador, L. A.; Serrano, P. E.; Kwan, J. C.; Zeller, S. L.; Chen, Q.; Ryu, S.; Liu, Y.; Byeon, S.; Luesch, H.; Hong, J. Evaluation of class I HDAC isoform selectivity of largazole analogues. Bioorg. Med. Chem. Lett. 2014, 24, 3728-3731.
  • Yu, M.; Salvador, L. A.; Sy, S. K.B.; Tang, Y.; Singh, R. S. P.; Chen, Q.; Liu, Y.; Hong, J.; Derendorf, H.; Luesch, H. Largazole Pharmacokinetics in Rats by LC-MS/MS. Mar. Drugs 2014, 12, 1623-40.
  • Salvador, L. A.; Taori, K. T.; Biggs, J. S.; Jakoncic, J.; Ostrov, D. A.; Paul, V. J.; Luesch, H. Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating 2 Lilibeth A. Salvador-Reyes cytoprotective and anti-inflammatory effects in bronchial epithelial cells. J. Med. Chem. 2013, 56, 1276–1290.
  • Liu, Y.; Zhang, W.; Li, L.; Salvador, L. A.; Chen, T.; Chen, W.; Felsenstein, K. M.; Ladd, T. B.; Price, A. R.; Golde, T. E.; He, J.; Xu, Y.; Li, Y.; Luesch, H. Cyanobacterial peptides as prototype for the design of potent -secretase inhibitors and the development of selective chemical probes for other aspartic proteases. J. Med. Chem. 2012, 55, 10749-10765.
  • Salvador, L. A.; Luesch, H. HDAC inhibitors and other histone modifying natural products as emerging anticancer agents. In Natural Products and Cancer Drug Discovery. Koehn, F. E., Ed.; Springer: New York, 2013; pp. 59-95. Salvador, L. A.; Luesch, H. Discovery and mechanism of natural products as modulators of histone acetylation. Curr. Drug Targets 2012, 13, 1029-1047.
  • Salvador, L. A.; Biggs, J. S.; Paul, V. J.; Luesch, H. Veraguamides A–G, cyclic hexapeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam. J. Nat. Prod. 2011, 74, 917-927.
  • Salvador, L. A.; Paul V. J.; Luesch, H. Caylobolide B, a macrolactone from symplostatin 1- producing marine cyanobacterium Phormidium spp. from Florida. J. Nat. Prod. 2010, 73, 1606- 1609.
  • Liu, Y.; Salvador, L. A.; Byeon, S.; Ying, Y.; Kwan, J. C.; Law, B. K.; Hong, J.; Luesch, H. Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. J. Pharmacol. Exp. Ther. 2010, 335, 351-361.
  • Matthew, S.; Salvador, L. A.; Schupp, P. J.; Paul, V. J.; Luesch, H. Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam. J. Nat. Prod. 2010, 73, 1544-1552.

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