Lilibeth A. Salvador-Reyes, Ph.D. – Professor, Deputy Director for Instruction

Contact:
lsreyes@msi.upd.edu.ph

Education:
Ph.D. in Pharmaceutical Sciences-Medicinal Chemistry, University of Florida

Research Interests:
Medicinal and Natural Products Chemistry, Biochemistry, Pharmacology

Selected Publications:

• Olano DEB, Salvador-Reyes LA, Montaño MNE, Azanza RV. 2020. Sorpiton of paralytic shellfish toxins (PSTs) in algal polysaccharide gels. Algal Research 45:101655.
• Tun JO, Salvador-Reyes LA, Velarde MC, Saito N, Suwanborirux K, Concepcion GP. (2019). Synergistic cytotoxicity of Renieramycin M and Doxorubicin in MCF-7 breast cancer cells. Marine Drugs, 17(9):536.
• Santiago VS, Manzano GG, Yu CC, Aliño PM, Salvador-Reyes LA. 2019. Mariculture potential of renieramycin-producing Philippine blue sponge Xestospongia sp. (Porifera: Haplosclerida). Aquaculture, 502:356-364.
• Liang X, Luo D, Yan J-L, Rezzaei MA, Salvador-Reyes LA, Gunasekera SP, Li C, Ye T, Paul VJ, Luesch H. (2019). Discovery of amantamide, a selective CXCR7 agonist from marine cyanobacteria. Org. Lett., 21(6):1622-1626
• Lacerna NM, Miller BW, Lim AL, Tun JO, Robes JMD, Cleofas MJB, Lin Z, Salvador-Reyes LA, Haygood MG, Schmidt EW, Concepcion GP. 2019. Mindapyrroles A−C, pyoluteorin analogues from a shipworm-associated bacterium. J. Nat. Prod. 82:1024−1028
• Cai, W.; Salvador-Reyes, L. A.; Zhang, W.; Chen, Q. Y.; Matthew, S.; Ratnayake, R.; Seo, S. J.; Dolles, S.; Gibson, D. J.; Paul, V. J.; Luesch H. Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing. ACS Chem Biol. 2018, 13, 91-99.
• Al-Awadhi, F. H.; Salvador, L. A.; Law, B. K.; Paul, V. J.; Luesch, H. Kempopeptin C, a novel marine-derived serine protease inhibitor targeting invasive breast cancer. Mar. Drugs 2017, 15, 290.
• Al-Awadhi, F.H.; Salvador, L.A.; Luesch, H. 2015. Screening strategies for drug discovery and target identification. Marine Biomedicine Beach Bedside. Boca Raton, Fl: CRC Press 135–166.
• Engene, N.; Tronholm, A.; Salvador-Reyes, L. A.; Luesch, H.; Paul, V. J. Caldora penicillata gen. nov., comb. nov. (Cyanobacteria), a pantropical marine species with biomedical relevance J. Phycol. 2015, 51, 670–681.
• Salvador-Reyes, L. A.; Sneed, J.; Paul, V.J.; Luesch, H. Amantelides A and B, Polyhydroxylated macrolides with differential broad-spectrum cytotoxicity from a Guamanian marine cyanobacterium. J. Nat. Prod. 2015, 78, 1957–1962.
• Salvador-Reyes, L. A.; Engene, N.; Paul, J.; Luesch, H. Targeted natural products discovery from marine cyanobacteria using combined phylogenetic and mass spectrometric evaluation. J. Nat. Prod. 2015, 78, 486–492.
• Salvador-Reyes, L. A. and Luesch, H. Biological targets and mechanisms of action of natural products from marine cyanobacteria. Nat. Prod. Rep. 2015, 32, 478–503.
• Salvador, L. A.; Park, H.; Al-Awadhi, F. H.; Liu, Y.; Kim, B.; Zeller, S. L.; Chen, Q.; Hong, J.; Luesch, H. Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties. ACS Med. Chem. Lett. 2014, 5, 905-910.
• Kim, B.; Park, H.; Salvador, L. A.; Serrano, P. E.; Kwan, J. C.; Zeller, S. L.; Chen, Q.; Ryu, S.; Liu, Y.; Byeon, S.; Luesch, H.; Hong, J. Evaluation of class I HDAC isoform selectivity of largazole analogues. Bioorg. Med. Chem. Lett. 2014, 24, 3728-3731.
• Yu, M.; Salvador, L. A.; Sy, S. K.B.; Tang, Y.; Singh, R. S. P.; Chen, Q.; Liu, Y.; Hong, J.; Derendorf, H.; Luesch, H. Largazole Pharmacokinetics in Rats by LC-MS/MS. Mar. Drugs 2014, 12, 1623-40.
• Salvador, L. A.; Taori, K. T.; Biggs, J. S.; Jakoncic, J.; Ostrov, D. A.; Paul, V. J.; Luesch, H. Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating 2 Lilibeth A. Salvador-Reyes cytoprotective and anti-inflammatory effects in bronchial epithelial cells. J. Med. Chem. 2013, 56, 1276–1290.
• Liu, Y.; Zhang, W.; Li, L.; Salvador, L. A.; Chen, T.; Chen, W.; Felsenstein, K. M.; Ladd, T. B.; Price, A. R.; Golde, T. E.; He, J.; Xu, Y.; Li, Y.; Luesch, H. Cyanobacterial peptides as prototype for the design of potent -secretase inhibitors and the development of selective chemical probes for other aspartic proteases. J. Med. Chem. 2012, 55, 10749-10765.
• Salvador, L. A.; Luesch, H. HDAC inhibitors and other histone modifying natural products as emerging anticancer agents. In Natural Products and Cancer Drug Discovery. Koehn, F. E., Ed.; Springer: New York, 2013; pp. 59-95. Salvador, L. A.; Luesch, H. Discovery and mechanism of natural products as modulators of histone acetylation. Curr. Drug Targets 2012, 13, 1029-1047.
• Salvador, L. A.; Biggs, J. S.; Paul, V. J.; Luesch, H. Veraguamides A–G, cyclic hexapeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam. J. Nat. Prod. 2011, 74, 917-927.
• Salvador, L. A.; Paul V. J.; Luesch, H. Caylobolide B, a macrolactone from symplostatin 1- producing marine cyanobacterium Phormidium spp. from Florida. J. Nat. Prod. 2010, 73, 1606- 1609.
• Liu, Y.; Salvador, L. A.; Byeon, S.; Ying, Y.; Kwan, J. C.; Law, B. K.; Hong, J.; Luesch, H. Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. J. Pharmacol. Exp. Ther. 2010, 335, 351-361.
• Matthew, S.; Salvador, L. A.; Schupp, P. J.; Paul, V. J.; Luesch, H. Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam. J. Nat. Prod. 2010, 73, 1544-1552.