Gisela P. Concepcion, Ph.D. – Professor Emeritus, Academician of the National Academy of Science and Technology (NAST)


Ph.D. Chemistry, University of the Philippines, Diliman

Research Interests:
Marine Natural Products, Biochemistry, Development of Bioscreening Methods

Selected Publications:

  • Torres JP, Lin Z, Fenton DS, Leavitt LU, Niu C, Lam P-Y, Robes JM, Pterson RT, Concepcion GP, Haygood MG, Olivera BM, Schmidt EW. 2020. Boholamide A, an APD-Class, Hypoxia-Selective Cyclodepsipeptide. Journal of Natural Products. Article in Press.
  • Miller BW, Torres JP, Flores MS, FOrteza I, Rosenber G, Haygood MG, Schmidt EW, Concepcion GP. 2020. Synergistic anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and absolute stereochemistry of 7,8-dideoxygriseorhodin C. Journal of Antibiotics. Article in Press
  • Tun JO, Salvador-Reyes LA, Velarde MC, Saito N, Suwanborirux K, Concepcion GP. (2019). Synergistic cytotoxicity of Renieramycin M and Doxorubicin in MCF-7 breast cancer cells. Marine Drugs, 17(9):536.
  • Shipway RJ, Rosenber G, Concepcion GP, Haygood MG, Savrda C, Distel DL. 2019. Shipworm bioerosion of lithic substrates in a freshwater setting, Abatan River, Philippines: Ichnologic, paleoenvironmental and biogeomorphical implications. PLoS ONE, 14(10):e0224551.
  • Shipway JR, Altamia MA, Rosenberg G, Concepcion GP, Haygood MG, Distel DL. 2019. Tamilokus mabinia, a new, anatomically divergent genus and species of wood-boring bivalve from the Philippines. PeerJ, 7:e6256a
  • Shipway RJ, Altamia MA, Rosenberg G, Concepcion GP, Haygood MG, Distel DL. (2019). A rock-boring and rock-ingesting freshwater bivalve (shipworm) from the Philippines. Proc Biol Sci., 286(1905):20190434
  • Lacerna NM, Miller BW, Lim AL, Tun JO, Robes JMD, Cleofas MJB, Lin Z, Salvador-Reyes LA, Haygood MG, Schmidt EW, Concepcion GP. 2019. Mindapyrroles A−C, pyoluteorin analogues from a shipworm-associated bacterium. J. Nat. Prod. 82:1024−1028
  • Altamia MA, Shipway JR, Concepcion GP, Haygood MG, Distel DL. 2019. Thiosocius teredinicola gen. nov., sp. nov., a sulfur-oxidizing chemolithoautotrophic endosymbiont cultivated from the gills of the giant shipworm, Kuphus polythalamius. Int J Syst Evol Microbiol 69(3):638-644.
  • Shipway JR, Altamia MA, Haga T, Velásquez M, Albano J, Dechavez R, Concepcion GP, Haygood MG, Distel DL. 2018. Observations on the life history and geographic range of the Giant Chemosymbiotic Shipworm Kuphus polythalamius (Bivalvia: Teredinidae). Biol Bull 235(3). DOI: 10.1086/700278
  • Belleza OJV, Tun JO, Concepcion GP, Villaraza AJL. 2018. On the inhibition of capsaicin response in dorsal root ganglion neurons by nobilamide B and analogues: a structure–activity relationship study. Med. Chem. Commun. 9:1673-1678.
  • Azcuna M, Tun JO, Yap HT, Concepcion GP. 2018. Callyspongia samarensis (Porifera) extracts exhibit anticancer activity and induce bleaching in Porites cylindrica (Scleractinia). Chem Ecol 34(5):397–411.
  • Torres, JP, Tianero MD, Robes JD, Kwan JC, Biggs JS, Concepcion GP, Olivera BB, Haygood MG, Schmidta EW. 2017. Stenotrophomonas-like bacteria are widespread symbionts in cone snail venom ducts. Appl. Environ. Microbiol. 83(23), Article number e01418-17.
  • Saito N, Hirade H, Sirinmangkalakitti N, Concepcion GP, Hiramatsu A, Kubota M, Fujino A, Suwanborinux K. 2017. Chemistry of renieramycins. 16. Structure of 7-demethylrenieramycin o (= 14α-hydroxyrenieramycin s) from blue sponge, Xestospongia sp. Heterocycles 95(2):748–752.
  • Omaga CA, Carpio LD, Imperial JS, Daly NL, Gajewiak J, Flores MS, Espino SS, Christensen S, Filchakova OM, López-Vera E, Raghuraman S, Olivera BM, Concepcion GP. 2017. Structure and Biological Activity of a Turripeptide from Unedo gemmula bisaya Venom. Biochemistry 56(45):6051–6060.
  • Lin Z, Smith MD, Concepcion GP, Haygood MG, Olivera, BM, Light A, Schmidt EW. 2017. Modulating the serotonin receptor spectrum of Pulicatin natural products. J. Nat. Prod. 80(8):2360–2370.
  • Distel DL, Altamia MA, Lin Z, Shipway R, Han A, Forteza I, Atemano R, Peñaflor-Limbaco MG, Tebo AG, Dechaves R, Albano J, Rosenberg G, Concepcion GP, Schmidt EW, Haygood MG . 2017. Discovery of chemoautotrophic symbiosis in t
  • Billones JB, Carrillo MCO, Organo VG, Sy JBA, Clavio NAB, Macalino SJY, Emnacen IA, Lee AP, Ko PL, and Concepcion GP. 2017. In silico discovery and in vitro activity of inhibitors against Mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase (Mtb BioA). Drug Des. Dev. Ther. 11:563–574.
  • Barghi N, Concepcion GP, Olivera BM, Lluisma AO. 2016. Structural features of conopeptide genes inferred from partial sequences of the Conus tribblei genome. Mol Genet Genomics, 291(1):411–422.
  • Barghi N, Concepcion GP, Olivera BM, Lluisma AO. 2016. Characterization of the complete mitochondrial genome of Conus tribblei Walls, 1977. Mitochondrial DNA A Mapp Seq Anal. 27(6):4451-4452.
  • Billones, J. B., Carrillo, M. C. O., Organo, V. G., Macalino, S. J. Y., Sy, J. B. A., Emnacen, I. A., Clavio, N. A. B, & Concepcion, G. P. (2016). Toward antituberculosis drugs: In silico screening of synthetic compounds against Mycobacterium tuberculosis L,D-transpeptidase 2. Drug design, development and therapy, 10, 1147.
  • Barghi, N., Concepcion, G. P., Olivera, B. M., & Lluisma, A. O. (2015). Characterization of the complete mitochondrial genome of Conus tribblei Walls, 1977. Mitochondrial DNA, 1-2.
  • Barghi, N., Concepcion, G. P., Olivera, B. M., & Lluisma, A. O. (2015). Structural features of conopeptide genes inferred from partial sequences of the Conus tribblei genome. Molecular Genetics and Genomics, 1-12.
  • Barghi, N., Concepcion, G. P., Olivera, B. M., & Lluisma, A. O. (2015). Comparison of the venom peptides and their expression in closely related Conus species: insights into adaptive post-speciation evolution of Conus exogenomes. Genome biology and evolution, 7(6), 1797-1814.
  • Barghi, N., Concepcion, G. P., Olivera, B. M., & Lluisma, A. O. (2015). High conopeptide diversity in Conus tribblei revealed through analysis of venom duct transcriptome using two high-throughput sequencing platforms. Marine Biotechnology, 17(1), 81-98.
  • Jacinto, M. P. V., Flores, M. S., Lin, Z., Concepcion, G. P., Schmidt, E. W., Faulkner, S., & Villaraza, A. J. L. (2014). Synthesis and bioactivity of nobilamide B. RSC Adv., 4(71), 37609-37612.
  • Arnaldo, F. B., Van Anthony, M. V., Konkalmatt, P. R., Owens, S. A., Asico, L. D., Jones, J. E., Yang, J., Lovett, D.L., Armando, I., Jose, P.A., & Concepcion, G. P. (2014). D1-like dopamine receptors downregulate Na+-K+-ATPase activity and increase cAMP production in the posterior gills of the blue crab Callinectes sapidus. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 307(6), R634-R642. |
  • Imperial, J. S., Cabang, A. B., Song, J., Raghuraman, S., Gajewiak, J., Watkins, M. Showers-Corneli, P., Fedosov, A., Concepcion, G.P., Terlai, H., Teichert, R. W., & Olivera, B.M. (2014). A family of excitatory peptide toxins from venomous crassispirine snails: Using constellation pharmacology to assess bioactivity. Toxicon, 89, 45-54.
  • Concepcion, G. P., Anas, A. R. J., & Azcuna, M. A. (2014). Anticancer compounds from Philippine marine organisms act on major pathways in cancer. Phil. Sci. Lett, 7, 207-227.
  • Lin, Z., Zachariah, M. M., Marett, L., Hughen, R. W., Teichert, R. W., Concepcion, G. P., Haygood, M.G., Olivera, B.M., Light, A.R., & Schmidt, E. W. (2014). Griseorhodins D–F, neuroactive intermediates and end products of post-PKS tailoring modification in griseorhodin biosynthesis. Journal of natural products, 77(5), 1224-1230.
  • Altamia, M. A., Wood, N., Fung, J. M., Dedrick, S., Linton, E. W., Concepcion, G. P., Haygood, M.G. & Distel, D. L. (2014). Genetic differentiation among isolates of Teredinibacter turnerae, a widely occurring intracellular endosymbiont of shipworms. Molecular ecology, 23(6), 1418-1432.
  • Molina, J., Hazzouri, K. M., Nickrent, D., Geisler, M., Meyer, R. S., Pentony, M. M., Flowers, J.M., Pelser, P., Barcelona, J., Inovejas, S.A., Uy, I. Yuan, W., Wilkins, O., Michel, C., Locklear, S., Concepcion, G.P., & Purugganan, M.D. (2014). Possible loss of the chloroplast genome in the parasitic flowering plant Rafflesia lagascae (Rafflesiaceae). Molecular biology and evolution, msu051.
  • Lin, Z., Koch, M., Pond, C. D., Mabeza, G., Seronay, R. A., Concepcion, G. P., Barrows, L.R., Olivera, B.M., & Schmidt, E. W. (2014). Structure and activity of lobophorins from a turrid mollusk-associated Streptomyces sp. The Journal of antibiotics, 67(1), 121-126.
  • Lin, Z., Marett, L., Hughen, R. W., Flores, M., Forteza, I., Ammon, M. A., Concepcion, G.P., Espino, S., Olivera B.M., Rosenberg, G., Haygood, M. G., Light, A.R., & Schmidt, E.W. (2013). Neuroactive diol and acyloin metabolites from cone snail-associated bacteria. Bioorganic & medicinal chemistry letters,23(17), 4867-4869.
  • Lin, Z., Torres, J. P., Ammon, M. A., Marett, L., Teichert, R. W., Reilly, C. A., Kwan, J.C., Highen, R.W., Flores, M., Tianero, M.D., Peraud, O., Cox, J.E., Light, A.R., Villaraza, A.J.L., Haygood, M.G., Concepcion, G.P., Olivera, B.M., & Schmidt, E.W. (2013). A bacterial source for mollusk pyrone polyketides. Chemistry & biology, 20(1), 73-81.
  • Elshahawi, S. I., Trindade-Silva, A. E., Hanora, A., Han, A. W., Flores, M. S., Vizzoni, V., Schrago, C.G., Soares, C.A., Concepcion, G.P., Distel, D.L., Schmidt, E. W., Haygood, M. G. (2013). Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills. Proceedings of the National Academy of Sciences, 110(4), E295-E304.
  • Betcher, M. A., Fung, J. M., Han, A. W., O’Connor, R., Seronay, R., Concepcion, G. P., Distel, D. L., & Haygood, M. G. (2012). Microbial distribution and abundance in the digestive system of five shipworm species (Bivalvia: Teredinidae). PLoS One, 7(9), e45309.
  • Tatsukawa, M., Punzalan, L. L. C., Magpantay, H. D., Villasenor, I. M., Concepcion, G. P., Suwanborirux, K. Yokoya, M., Saito, N. (2012). Chemistry of renieramycins. Part 13: Isolation and structure of stabilized renieramycin type derivatives, renieramycins W–Y, from Philippine blue sponge Xestospongia sp., pretreated with potassium cyanide. Tetrahedron, 68(36), 7422-7428
  • Olivera, B. M., Watkins, M., Bandyopadhyay, P., Imperial, J. S., de la Cotera, E. P. H., Aguilar, M. B., Vera, E. L., Concepcion, G. P., & Lluisma, A. (2012). Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes. Annals of the New York Academy of Sciences, 1267(1), 61-70.
  • Lin, Z., Flores, M., Forteza, I., Henriksen, N. M., Concepcion, G. P., Rosenberg, G., Haygood, M. G., Olivera, B. M., Light, A. R., Cheatham, T. E., & Schmidt, E. W. (2012). Totopotensamides, polyketide–cyclic peptide hybrids from a mollusk-associated bacterium Streptomyces sp. Journal of natural products, 75(4), 644-649.
  • Cabang, A. B., Imperial, J. S., Gajewiak, J., Watkins, M., Corneli, P. S., Olivera, B. M., & Concepcion, G. P. (2011). Characterization of a venom peptide from a crassispirid gastropod. Toxicon, 58(8), 672-680
  • Lin, Z., Reilly, C. A., Antemano, R., Hughen, R. W., Marett, L., Concepcion, G. P., Haygood, M. G., Olivera, B. M., Light, A., & Schmidt, E. W. (2011). Nobilamides A–H, long-acting transient receptor potential vanilloid-1 (TRPV1) antagonists from mollusk-associated bacteria. Journal of medicinal chemistry, 54(11), 3746-3755. |
  • Fedosov, A., Watkins, M., Heralde, F. M., Corneli, P. S., Concepcion, G. P., & Olivera, B. M. (2011). Phylogeny of the genus Turris: Correlating molecular data with radular anatomy and shell morphology. Molecular phylogenetics and evolution, 59(2), 263-270.
  • Yu, P., Han, W., Van Anthony, M. V., Li, H., Arnaldo, F. B., Concepcion, G. P., Felder, R. A., Quinn, M. T., & Jose, P. A. (2011). Dopamine D 1 receptor-mediated inhibition of NADPH oxidase activity in human kidney cells occurs via protein kinase A–protein kinase C cross talk. Free Radical Biology and Medicine, 50(7), 832-840.
  • Lin, Z., Antemano, R. R., Hughen, R. W., Tianero, M. D. B., Peraud, O., Haygood, M. G., Concepcion, G. P., Olivera, B. M., Light, A., & Schmidt, E. W. (2010). Pulicatins A− E, neuroactive thiazoline metabolites from cone snail-associated bacteria. Journal of natural products, 73(11), 1922-1926.
  • Coombs, G. S., Yu, J., Canning, C. A., Veltri, C. A., Covey, T. M., Cheong, J. K., Utomo, V., Banerjee, N., Zhang, Z. H., Jadulco, R. C., Concepcion, G. P., Bugni, T. S., Harper, M. K., Mihalek, I., Jones, C. M., Ireland, C. M., & Virshup, D. M. (2010). WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. Journal of cell science,123(19), 3357-3367.
  • Tasdemir, D., Marshall, K. M., Mangalindan, G. C., Concepcion, G. P., Barrows, L. R., Harper, M. K., & Ireland, C. M. (2001). Deoxyamphimedine, a new pyridoacridine alkaloid from two tropical Xestospongia sponges. The Journal of organic chemistry, 66(9), 3246-3248.
  • Heralde Iii, F. M., Kantor, Y. I., Astilla, M. A. Q., Lluisma, A. O., Geronimo, R., Aliño, P. M., Watkin, M., Showers-Corneli, P., Olivera, B. M., Santos, A. D., & Concepcion, G. P. (2010). The Indo-Pacific Gemmula species in the subfamily Turrinae: aspects of field distribution, molecular phylogeny, radular anatomy and feeding ecology. Philippine science letters, 3(1).
  • David, M. P. C., Concepcion, G. P., & Padlan, E. A. (2010). Using simple artificial intelligence methods for predicting amyloidogenesis in antibodies. BMC bioinformatics, 11(1), 1.
  • Concepcion, G. P., & Padlan, E. A. (2009). Do prions aggregate in response to electrical stimulation and does this play a role in long-term memory?. Bioscience Hypotheses, 2(1), 24-26. |
  • Seronay, R. A., Fedosov, A. E., Astilla, M. A. Q., Watkins, M., Saguil, N., Heralde, F. M., Tagaro, S., Poppe, G. T., Aliño, P. M., Kantor, Y. I., Concepcion, G. P., & Olivera, B. M. (2010). Accessing novel Conoidean venoms: Biodiverse lumun-lumun marine communities, an untapped biological and toxinological resource. Toxicon, 56(7), 1257-1266.
  • Concepcion, G. P., & Padlan, E. A. (2010). Does the electrical activity of neurons contribute to the pathogenesis of Alzheimer’s Disease?. Medical hypotheses, 74(1), 27-28.
  • McCulloch, M. W., Bugni, T. S., Concepcion, G. P., Coombs, G. S., Harper, M. K., Kaur, S., Mangalindan, G. C., Mutizwa, M. M., Veltri, C. A., Virship, D. M., & Ireland, C. M. (2009). Carteriosulfonic acids A− C, GSK-3β inhibitors from a Carteriospongia sp. Journal of natural products,72(9), 1651-1656. |
  • Peraud, O., Biggs, J. S., Hughen, R. W., Light, A. R., Concepcion, G. P., Olivera, B. M., & Schmidt, E. W. (2009). Microhabitats within venomous cone snails contain diverse actinobacteria. Applied and environmental microbiology, 75(21), 6820-6826.
  • Whitson, E. L., Bugni, T. S., Chockalingam, P. S., Concepcion, G. P., Feng, X., Jin, G., Harper, M. K., Mangalinda, G. C., McDonald, L. A., Ireland, C. M., & Ireland, C. M. (2009). Fibrosterol sulfates from the Philippine sponge Lissodendoryx (Acanthodoryx) fibrosa: sterol dimers that inhibit PKCζ. The Journal of organic chemistry, 74(16), 5902-5908.
  • Mazahery, A. R. F., Dator, R. P., Concepcion, G. P., & Jacinto, S. D. (2009). Murihexocin C from the leaves of Annona squamosa Linn. induces apoptosis in human colon carcinoma Col 2 cell line. Philippine Agricultural Scientist, 92(2), 122-132
  • Heralde III, F. M., Watkins, M., Ownby, J. P., Bandyopadhyay, P. K., Santos, A. D., Concepcion, G. P., & Olivera, B. M. (2007). Molecular phylogeny of some Indo-Pacific genera in the subfamily Turrinae H. Adams and A. Adams, 1853 (1838)(Gastropoda: Neogastropoda). Nautilus, 121(3), 131-138.
  • Marshall, K. M., Andjelic, C. D., Tasdemir, D., Concepcion, G. P., Ireland, C. M., & Barrows, L. R. (2009). Deoxyamphimedine, a pyridoacridine alkaloid, damages DNA via the production of reactive oxygen species. Marine drugs, 7(2), 196-209.
  • Amor, E. C., Villaseñor, I. M., Antemano, R., Perveen, Z., Concepcion, G. P., & Choudhary, M. I. (2007). Cytotoxic C-methylated chalcones from Syzygium samarangense. Pharmaceutical Biology, 45(10), 777-783.
  • Whitson, E. L., Bugni, T. S., Chockalingam, P. S., Concepcion, G. P., Harper, M. K., He, M., Hooper, J. N. A., Mangalindan, G. C., Ritacco, F., & Ireland, C. M. (2008). Spheciosterol sulfates, PKCζ inhibitors from a Philippine sponge Spheciospongia sp. Journal of natural products, 71(7), 1213-1217.
  • Concepcion, G. P. (2008, June). Biological structures, interactions, function and behavior: Research opportunities for physicists. In Stochastic and Quantum Dynamics of Biomolecular Systems: Proceedings of the 5th Jagna International Workshop (Vol. 1021, No. 1, pp. 121-138). AIP Publishing.
  • Heralde, F. M., Imperial, J., Bandyopadhyay, P. K., Olivera, B. M., Concepcion, G. P., & Santos, A. D. (2008). A rapidly diverging superfamily of peptide toxins in venomous Gemmula species. Toxicon, 51(5), 890-897.
  • Punzalan, G. A. N., Concepcion, G. P., Dator, R. P., Mazahery, A., & Jacinto, S. D. (2008). P7 Flavonoid-positive plant fractions yield a potent inducer of promyelocytic leukemia cell differentiation with no enzyme inhibitory action within the XO system. European Journal of Cancer Supplements, 6(3), 43.
  • Sertan-de Guzman, A. A., Predicala, R. Z., Bernardo, E. B., Neilan, B. A., Elardo, S. P., Mangalindan, G. C., Tasdemir, D., Ireland, C. M., & Concepcion, G. P. (2007). Pseudovibrio denitrificans strain Z143-1, a heptylprodigiosin-producing bacterium isolated from a Philippine tunicate. FEMS microbiology letters,277(2), 188-196.
  • David, M. P. C., Asprer, J. J. T., Ibana, J. S. A., Concepcion, G. P., & Padlan, E. A. (2007). A study of the structural correlates of affinity maturation: antibody affinity as a function of chemical interactions, structural plasticity and stability. Molecular immunology, 44(6), 1342-1351.
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